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The minimum evaluation of a patient suspected of nontuberculous mycobacterial (NTM) lung disease should include the following: ( 1) chest radiograph or, in the absence of cavitation, chest high-resolution computed tomography (HRCT) scan; ( 2) three or more sputum specimens for acid-fast bacilli (AFB) analysis; and ( 3) exclusion of other disorders, such as tuberculosis (TB).

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Corneal opacity occurred in dogs at doses 12 times and in monkeys at doses 8 times greater than the maximum human daily dose (on a body surface area basis).

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Chronic granulomatous infection caused by NTM may develop in tendon sheaths, bursae, joints, and bones after direct inoculation of the organisms through accidental traumas, surgical incisions, puncture wounds, or injections including intraarticular or bursal steroids.

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During the first four weeks of therapy, while patients were maintained on their originally assigned dose, there were 11 deaths in 255 patients taking 500 mg twice daily and 18 deaths in 214 patients taking 1000 mg twice daily.

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Patients who complete 10 to 12 months of negative cultures on therapy, however, but then have either single or multiple positive MAC cultures are more likely to have reinfection with a new MAC strain.

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Drugs with pH-Dependent Absorption Kinetics: Due to its effects on gastric acid secretion, lansoprazole can reduce the absorption of drugs where gastric pH is an important determinant of their bioavailability.

On the back of the bottle, it showed how to properly take it (proper dosage, using distilled water, etc) but it said nothing about being on an empty stomach.

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The major therapeutic advance in the treatment of pulmonary MAC disease was the introduction of the newer macrolides, clarithromycin and azithromycin, which have substantial in vitro and clinical activity against MAC.

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