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Also, there is speculation that when patients who are using remicade use only once in a while, and not on a specific schedule, they have a higher chance of developing antibodies to the medication which make it less or not useful at all moving forward.

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Thus the use of this class of medications must into account their relative risks in an individual patient of gastrointestinal damage versus potential cardiovascular risk factors.

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Serum bilirubin and prothrombin time were normal and all tests for viral hepatitis and autoimmune markers were negative.

Over time CRMO seems to follow a course of waxing and waning symptoms, but when associated with colitis, while there is limited literature, a reasonable target would seem to be control of the bowel disease first with specific and independent therapeutic consideration of CRMO only if symptoms linger once the bowel disease is quiescent.

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