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The guidelines further agree that culture should be performed in all cases of upper or complicated UTI, since diagnosis can be difficult, the microbial etiology is different, antimicrobial resistance is more common, and complications are more frequent.
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Therapy should be continued for approximately 4 to 6 weeks, depending on the nature and severity of the infection.
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Ultimately, the quinolones exert their antibacterial effect by binding to complexes of DNA and topoisomerase II or IV, which leads to interference in the DNA replication process.
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Importantly, amiodarone has a very long half-life and therefore may be present in the liver for several months after withdrawal of therapy.
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Hepatocellular injury can be caused by drugs that rarely, if ever, cause severe liver injury (eg, aspirin, tacrine, statins, heparin), as well as by drugs that do cause such injury.
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These guidelines are important to all of the medical community as well as clinical microbiology laboratories, and the group offered any support needed by that committee when the topic of urine cultures is addressed.
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Theophylline levels should be closely monitored and theophylline dosage adjustments made, if appropriate, when Ofloxacin is co administered.
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The most commonly encountered underlying disease is malignancy, which was noted in a significant proportion (44%) of the patients.
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