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Beyond these strategies, the following medication strategies have been found to be helpful.

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Exposure to certain toxins has caused parkinsonian symptoms in rare circumstances (such as exposure to MPTP, an illicit drug, or in miners exposed to the metal manganese).

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Amantadine (Symmetrel), which has a longer half-life than levodopa, appears to act synergistically with levodopa and thus has been considered useful in the treatment of early Parkinson's disease.

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