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How long does it take for mifepristone to work? How long does it take for the abortion to complete? The second pill, Misoprostol, is taken 24 to 48 hours after the first pill, Mifepristone, is taken. Approximately half will experience the heavy cramping and bleeding necessary to expel the embryo, uterus lining, and embryonic sac within the first five hours.
Can misoprostol be taken sublingually? Administration under the tongue (sublingually) of the abortion medication misoprostol is most effective when taken in three hour intervals, but this can cause more side effects than when taken every 12 hours.
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